Bob Hoskins has died from pneumonia at the age of 71, his agent has announced.
The actor, who was best known for roles as cockneys and gangsters, achieved global fame after appearing in blockbusters Who Framed Roger Rabbit? and Hook.
During a glittering four-decade career, Hoskins picked up the prestigious Cannes Prix d'interprétation masculine as well as winning a best actor Bafta and Golden Globe.
He was forced to retire from acting in 2012 after he was diagnosed with Parkinson's disease.
His wife Linda and children Alex, Sarah, Rosa and Jack said: "We are devastated by the loss of our beloved Bob.
"Bob died peacefully in hospital last night, surrounded by family, following a bout of pneumonia.
"We ask that you respect our privacy during this time and thank you for your messages of love and support."
Legend had it Hoskins only became an actor after someone told him to audition for a play that was being cast in the pub where he was drinking.
Born in Bury St Edmunds, Suffolk, he first captivated audiences when he was cast in a TV version of Pennies from Heaven in 1978.
His career rocketed during the 1980s with a string of critically acclaimed hits, including The Long Good Friday and Brazil, in which he starred alongside Robert DeNiro.
Hoskins was nominated for an Oscar for 1986's Mona Lisa with a performance that also saw him win the Cannes, Golden Globe and Bafta prizes.
Commercial success followed in the shape of neo-noir hit Who Framed Roger Rabbit? followed by a starring role alongside Dustin Hoffman in Steven Speilberg's Peter Pan-inspired Hook.