Juan Mata's vital away goal in the first leg provides Chelsea with some hope of overturning their two-goal deficit at home to Napoli on Wednesday evening.
The Blues will hope to succeed where Arsenal failed last week, by overturning the 3-1 defeat they suffered in Naples three weeks ago to reach the quarter-finals of the Champions League.
Chelsea suffered a humiliating defeat at the Stadio San Paolo in the first leg but Mata's first-half strike means they require just a 2-0 victory to qualify.
Napoli's win helped contribute to Andre Villas-Boas' departure as Chelsea boss and caretaker manager Roberto Di Matteo will hope his backline can deal with the threat of Uruguayan forward Edinson Cavani.
Recent Castrol EDGE Performance data suggests the Naples striker is a more clinical finisher than Didier Drogba this season, having converted 24 per cent of his chances, compared to 15 per cent for the Ivorian international.
However, the Chelsea striker has been more efficient in the air than his Uruguayan counterpart, with a 29 per cent headed shots conversion in contrast to Cavani's 10 per cent success rate.
Cavani scored Napoli's second in the first-leg clash as the Italian's established a healthy lead and the striker has warned Chelsea that they only require a solitary strike to advance into the next round.
"Scoring at Chelsea's ground will mean qualification and that's our goal for Wednesday," the 25-year-old is quoted on Goal.com.
"At the San Paolo we showed our ability to overcome difficulties and we put in a lot of effort. Now, in London, we will have to combine sacrifice with success in front of goal."
John Terry's remarkable recovery from knee surgery means he is expected to partner Gary Cahill at the heart of Chelsea's defence. Raul Meireles serves a one-match ban after picking up his third yellow card of the season in the first leg, so Michael Essien or John Obi Mikel are likely to start in midfield.
Didier Drogba should keep his place after scoring the solitary goal in Saturday's victory over Stoke, with Daniel Sturridge and Mata also expected to start.