Theo Walcott is a doubt for England's Euro 2012 qualifier at home against Wales on Tuesday, with Leighton Baines, Darren Bent and Micah Richards also missing from Fabio Capello's squad.
Capello has indicated he is ready to make changes to the line-up that beat Bulgaria 3-0 on Friday, with the need to nullify the threat posed by Wales' Gareth Bale a particular concern.
Frank Lampard could be in line for a return in the centre of midfield, while Jermain Defoe is a likely strike-partner for Wayne Rooney.
The Italian is understood to be considering a switch from 4-2-3-1 to an attacking 4-3-3 formation, with Ashley Young joining Defoe and Rooney up front.
England's winless home record stretches back 12 months to the 4-0 victory over Bulgaria, and Capello remains wary of tonight's opposition, despite the absence of the suspended Craig Bellamy and David Vaughan.
"Bale always makes a difference. He is a really, really important player for Wales," Capello said. "We need to find a system to stop him and stop people passing him. We need to be very careful every time he receives the ball."
A victory against Wales will take England to within one point of automatic qualification for next summer's European Championships, with Montenegro still to play on 7 October.
However, Wales' position at the foot of Group G belies their recent form. Gary Speed's side beat Montenegro 2-1 in Cardiff on Friday and the Wales manager is confident his side can put a buffer on England's recent good form.
"England are by far the best team in the group and they will qualify comfortably but hopefully for our sake it won't be on Tuesday night," he said.
"We did them a favour on Friday but we're thinking about ourselves and getting a result purely for ourselves."
Meanwhile, England captain John Terry has told Andy Carroll to learn from his mistakes after Capello questioned the Liverpool striker's fitness amidst on-going concerns over his lifestyle.
Yesterday, the Italian claimed Carroll "needs to drink less than others" if he hopes to regain his England place.
However, Terry believes the lessons he learnt earlier in his career can help the 22-year-old regain the form that prompted Liverpool to pay £35m for him in January.
"He's a young player who's at a very good club with a really good future," he said.
"He has still got to enjoy his time away from football. I'm sure he will. He's a really good pro on the pitch and good around the camp. I've made my mistakes, maybe drunk a little bit too much when I was younger and gone out a little bit too much.
"But, having gone through that, at 26 or 27 you maybe look back and are glad you did it then because you don't want to do it now."
Possible starting XI: Hart, Smalling, Terry, Cahill, Cole, Parker, Lampard, Barry, Young, Rooney, Defoe.