Defending European champions Spain will look to bounce back from their shock warm-up defeat against Georgia by winning their Euro 2016 Group D opener versus the Czech Republic at the Stade de Toulouse on 13 June.
Vicente del Bosque's side have endured a tough week, losing to 137th-ranked Georgia at home. La Roja won all but one of their qualifying games, but have only won two of their last five friendly matches.
They are backed at 8/17 by Betfair to begin their title defence with a win.
The Czech Republic also lost their final warm-up match, suffering a 2-1 defeat against South Korea in Prague. Pavel Vrba's men have only won two of their six international friendlies – a sequence that included defeats against Scotland and Poland. They are 17/2 to beat Spain in Toulouse, while a draw is priced at 7/2.
Athletic Bilbao forward Aritz Aduriz and Juventus striker Alvaro Morata are both evenly-priced at 9/2 to score the first goal of the match.
Spain have only kept one clean sheet in their last five matches and are a 6/5 bet to win the match without conceding.