A person has died after a lorry fell off a bridge onto the M56 near Daresbury.
Firefighters and an air ambulance are currently on the scene.
There are no other reported casualties.
The incident happened around junction 11 and the M56 is now closed in both directions.
The A56 above the motorway leading from Preston Brook to Warrington is also closed to traffic.
"Motorists are strongly advised to avoid the M56 in the vicinity of Warrington and Runcorn and to seek alternative routes," said a statement from Cheshire police.
"The motorway is expected to be closed for several hours and this will impact heavily upon rush hour traffic in and around Warrington."
This latest accident comes after the 34-car pile-up on the M5 on Nov. 4 killed seven and injured 51.