Inter Milan and Roma will be looking to kick start 2011/12 Serie A campaigns after opening day defeats to Palermo and Cagliari respectively.
Inter Milan also were defeated in their opening UEFA Champions League match with Turkish side Trabzonspor and the pressure is mounting on both the players and new boss Gian Piero Gasperini, however Inter Milan captain Javier Zanetti is convinced the clubs start to the season is just a blip and has told the press the manager has the full support of the Inter Milan players.
"No-one expected such a start," Zanetti said.
We are disappointed but this is only the beginning. I know this group can respond positively. We want to win on Saturday night and change the trend. During a season, you have moments of difficulty and we hope this is just one of them," he added.
Roma new boss Luis Enrique is also under pressure after his sides defeat to Cagliari in the first round of matches. The Roma boss has said that he sees his side are improving and expects his side to find their rhythm at the San Siro.
"I am optimistic," Luis Enrique said.
"We have a good group of players. We only just started a new project, we are eager to work. The results have not arrived yet but I've seen things that I've really liked," the Roma boss added.
Inter Milan are on a run of 13 consecutive wins at home in Serie A, and are unbeaten since the derby loss against AC Milan in November and in nine of these 13 games Inter have scored three or more goals.
Roma won four of their last six games played away from home last season.
Inter (4-3-1-2):Julio Cesar; Jonathan, Ranocchia, Lucio, Nagatomo; Zanetti, Cambiasso, Obi; Sneijder; Pazzini, Forlan
Roma (4-3-3): Stekelenburg; Rosi, Burdisso, Heinze, Cassetti; Perrotta, De Rossi, Pjanic; Borriello, Totti, Borini
Prediction: Inter Milan 3-2 Roma