Ryan Bertrand and Jonjo Shelvey have joined England's squad for the World Cup qualifiers against San Marino and Poland after Arsenal full-back Kieran Gibbs pulled out through injury.
While Bertrand is a replacement for Gibbs as one of three left backs in the squad, Shelvy wins his first calls up having been promoted from the Under-21's as a cover for Frank Lampard.
Shelvey has already scored three times for Liverpool this season, while Bertrand, who has two England caps to his name and played for Team GB during the Olympic Games, featured in the Champions League final for Chelsea in May.
Bertrand's call-up comes at the expense of Gibbs, who has a thigh strain, and adds to the major injury list for Arsenal.
Abou Diaby, Wojciech Szczesny, Lukas Fabianski and Tomas Rosicky are all currently out injured, while Jack Wilshere and Bacary Sagna are yet to fully return despite making brief appearances for The Gunners' Under-21 side.
Gibbs has previously suffered a succession of foot problems, but having established himself as the first-choice full-back in the Arsenal team ahead of Andre Santos, looks likely to spend a period out of the first-team picture.
Theo Walcott and Alex Oxlade-Chamberlain remain the only representatives from Arsenal, and Arsene Wenger will be hoping for no further injuries as he looks to protect an impressive start to the season.
Former Charlton Athletic player Shelvey meanwhile becomes the latest Liverpool youngster to be noticed by Roy Hodgson, after Raheem Sterling was called up for the qualifier against Ukraine.
Sterling has been included in the England Under-21 squad for the two-legged Euro 2013 qualifier against Serbia along with Liverpool teammates Andre Wisdom and Jordan Henderson.
"For Raheem, to have an insight into the senior team, is fantastic," Under-21 boss Stuart Pearce said. "He's been in our development squads and has done extremely well for Liverpool, and credit to Brendan [Rodgers] who has given him his chance. We are pleased to have him."