Warsaw police have detained 120 Lazio supporters after they hurled stones and bottles at police vans ahead of the Europa League match against Legia Warsaw.
The suspects "may not see the match", police spokesman Andrzej Browarek said.
The vans were deployed in Warsaw's main Marszalkowska street to ensure security before and after the game.
Lazio were due to play the Polish league champions at Legia's 32,000-capacity stadium.
Five Lazio fans were attacked by Legia supporters who broke into the hotel where the Italians were staying, according to daily La Repubblica.
Police raided the rooms of 17 Lazio supporters and found a bag containing sharp objects". All the fans whose rooms were raided were forced to take the flight back to Rome.
Lazio fans have a notorious reputation, with a strong hooligan hardcore known as the Irriducibili.
In 2012, twoTottenham Hotspur fans were stabbed in a night assault in a Rome pub by around 100 masked Lazio hooligans.
The latter have long been associated with far-right politics and a wide range of banners are often unveiled on the Curva Nord end of the Stadio Olimpico including some showing support for Arkan, the Serbian war criminal, and glorifying the Auschwitz concentration camp.
Former Lazio manager Paulo Di Canio, now at Swindon, infamously celebrated a goal by running to the crowd and giving the Irriducibili Mussolini's fascist salute after Lazio scored during the Rome derby. Former dictator Benito Mussolini was himself a big Lazio fan who often went to games.