Liverpool manager Brendan Rodgers has confirmed Daniel Sturridge, Glen Johnson, Emre Can, Jon Flanagan and Marin Skrtel will all miss the game against Aston Villa on Saturday due to injuries – while Joe Allen is also a doubt.
The Merseyside team hosts Paul Lambert's side in search of their third Premier League victory of the season, following their impressive win over Tottenham just before the international break.
However, the Liverpool boss will have to piece together his starting line-up without some crucial players.
Rodgers confirms Sturridge will be out "up to three weeks" after injuring his thigh during an England training session at St George's Park.
He has previously said that the injury could have been prevented, but has refused to blame Roy Hogson for it.
"I think there's good communication. I speak regularly with Roy. Roy's probably been led by some of the experts he has around him and for whatever reason Dan was deemed able to train. One recovery doesn't fit everyone."
At the same time Rodgers says Emre Can could be out for "up to six weeks" after hurting his ankle with Germany.
"Glen Johnson's still got a week to go. Jon Flanagan is edging towards but no in the squad yet. Adam Lallana is back in, he's fine" Rodgers added.
"And we'll assess Joe Allen. He has an issue with his knee."
When questioned about whether Rickie Lambert will replace Sturridge up-front, Rodgers said: "Rickie's working very well and if he doesn't start he will certainly start against Middlesbrough in the Capital One Cup.
"Rickie's working very well and if he doesn't start he will certainly start against Middlesbrough in the Capital One Cup."
Meanwhile Rodgers demanded more patience on Sterling, saying: "He needs protection. I've seen it over the years. He's a wonderful talent and been great for Liverpool. He's a very mature boy for his age. His performances have been exceptional but we need to be careful.
"Especially with England, they tend to look for one player to put up on a pedestal and then they are very quick to knock them down."