Sunday, 18 September
Kick-off: 1600 BST
Last season: Manchester United 2 1 Chelsea
Where to watch: In the U.K., Sky Sports and ESPN will share live coverage and highlights, while Match of the Day will broadcast a comprehensive highlights program on Saturday and Sunday nights, full details are available on the BBC Web site. In the U.S., Fox Sports and ESPN will show select matches and highlights, check their individual TV schedules for further details.
Indian fans will have to contend with ESPN Star's coverage, full details are available on the company's website.
For all other countries, the official Premier League website has a comprehesive list of broadcasters. Further live online coverage of Saturday afternoon matches from around the world is available here.
Preview: Andre Villas-Boas faces his first real test as Chelsea manager when he takes his side to Old Trafford on Sunday to face an in-form Manchester United.
Sir Alex Ferguson's side have won their last three matches with Chelsea in all competitions, with Sunday's game likely to provide a clue as to the destination of this season's title.
Villas-Boas's side have been quietly impressive during the opening weeks off the season. After the goalless draw at Stoke on the opening day the Blues have recorded three straight wins in the Premier League and opened their Champions League campaign with a 2-0 victory over Bayer Leverkusen.
Didier Drogba is likely to miss Sunday's game as he continues his recovery from a serious head injury, with long-term absentee Michael Essien also ruled out.
Defender David Luiz is expected to retain his place alongside John Terry, with midfielder Ramires available after a European suspension.
Sir Alex Ferguson has no new injury concerns following the mid-week Champions League draw with Benfica.
Nemanja Vidic (calf), Tom Cleverly (foot) and Rafael (shoulder) are all still side-lined, while Danny Welbeck (hamstring) is yet to recover full fitness.
Ferguson is likely to revert to his first XI after fielding a weakened side against Benfica. David de Gea is expected to replace Anders Lindegaard in goal, despite the latter's impressive display in Portugal.
Javier Hernandez, Ashley Young, Nani and Anderson are also set to return, with Rio Ferdinand likely to return from injury.
Prediction: Man Utd 2 0 Chelsea
Man Utd possible XI: De Gea; Smalling, Ferdinand, Jones, Evra; Nani, Carrick, Anderson, Young; Rooney, Hernandez.
Chelsea probable XI: Cech; Cole, Terry, Ivanovic, Bosingwa; Lampard, Meireles, Ramires; Mata, Torres, Anelka.