Hosts have two wickets left in hand and require 33 more runs to seal historic victory.
The Gunners were well below their best against Middlesbrough in North London.
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Rooney, 30, has lost his place in the United team after a series of poor performances.
Rooney last started in the Premier League during Manchester United's defeat to Watford.
Anfield icon looks set to depart Major League Soccer when his current contract expires next month.
Jack Wilshere's future is away from Arsenal says ex-Tottenham and Liverpool midfielder Jamie Redknapp
Wilshere is on a season-long loan at AFC Bournemouth.