England fly-half Owen Farrell has been passed fit for the crunch Six Nations Championship and Grand Slam decider against Wales at the Millenium Stadium, while fellow half-back Ben Youngs and loosehead prop Joe Marler both return to Stuart Lancaster's Starting XV.
Farrell missed the 18-11 win over Italy on Sunday after suffering from a thigh problem during the victory over France, and replaces Toby Flood at 10 with Danny Care dropping to the bench in place of Youngs.
Tom Croft, after making his international return from a serious neck injury against Italy, comes in from the start in place of James Haskell, one of two changes in the pack, as Mako Vunipola makes way for Marler.
"As a whole squad we have come a long way through the QBE series and the Six Nations and we want to finish the job on what will be a fantastic occasion in Cardiff," Lancaster said.
"Every single player, whether they are in the 23 or not this Saturday, has contributed to getting us in this position and they should be proud of that.
"As coaches we have had to make some tough calls but this is a squad effort and I know those not involved will, like the whole nation, be behind us come 5 o'clock."
Joe Launchbury's elbow injury and Geoff Parling's shoulder problem, which forced him off against Italy, left both as injury doubts for the final Six Nations match in Cardiff, but the locks have made a sufficient recovery.
Wales require a victory by seven points or more providing they score no more than two tries less than England on Saturday. Anything less, and England would win the Six Nations while victory would deliver their first grand slam since 2003.
Without coach Warren Gatland, who is on Lions duty ahead of the tour to Australia this summer, Wales began the championship with defeat to Ireland, prior to wins over France, Italy and Scotland last weekend.
Gatland has already admitted the match will play a significant part in both his selection for the Lions tour and his choice as captain, with Sam Warburton, who is returning to captain the home side, going head-to-head with Chris Robshaw.
England: Goode, Ashton, Tuilagi, Barritt, Brown, Farrell, B Youngs, Marler, T Youngs, Cole, Launchbury, Parling, Croft, Robshaw, Wood.
Replacements: Hartley, Wilson, Vunipola, Lawes, Haskell, Care, Flood, Twelvetrees.