Tottenham Hotspur forward Erik Lamela was forced to sit out part of a training session with Argentina after suffering a muscle strain, according to Argentine newspaper Ole.
Lamela, 23, came off the bench with 10 minutes remaining in Saturday's 1-1 draw with Brazil but could now be a doubt for Tuesday's World Cup qualifier against Colombia.
Ole report the former Roma star was unable to train properly after feeling some muscular discomfort on Sunday 15 November, while Napoli striker Gonzalo Higuain was also troubled by an ankle problem.
There is no indication yet of the severity of the issue but Tottenham and Mauricio Pochettino will be hopeful it is nothing serious, with a key fixture against London rivals Chelsea awaiting. Tottenham also take on West Ham United on Sunday 22 November but the forward is suspended for that match.
Tottenham have a number of their important first team members away on international duty this week. Summer signing Heung min-Son, who has also struggled with injury problems of his own in recent weeks, provided two assists as he helped South Korea defeat Myanmar 4-0 and is likely to feature again against Laos on Tuesday.
Kyle Walker and Harry Kane played the full 90 minutes as England lost 2-0 to Spain while Dele Alli and Eric Dier – the latter who was making his international debut – came off the bench with just under half an hour remaining on Friday 13 November.
Toby Alderweireld and Jan Vertonghen played a full 90 minutes as Belgium defeated Italy 3-1 at the King Baudouin Stadium in Brussels on the same night, while Christian Eriksen was unable to prevent Denmark losing 2-1 to Sweden in the first leg of their European Championship play-off.
Midfielder Nabil Bentaleb has missed Tottenham's last 13 games after suffering an ankle injury in September but was played the entire second half of Algeria's 2-2 draw with Tanzania, while Clinton N'Jie lasted an hour in Cameroon's 3-0 win over Niger.