Chelsea are fretting over the fitness of midfielders Marco van Ginkel and Ramires ahead of the Premier League trip to Tottenham Hotspur after the duo both picked up injuries in the League Cup third round win at Swindon Town.
Van Ginkel was replaced by Ramires after just 10 minutes at the County Ground with a knee problem while the Brazilian, after scoring The Blues' second, was substituted at half-time with club captain John Terry taking his place after picking up a hip injury.
While Van Ginkel has made four appearances this season and would have been expected to start on the bench for the visit of Tottenham, Ramires has started every Premier League game this term and would likely have been considered to start at White Hart Lane.
But Chelsea assistant Steve Holland says the pair are both serious doubts ahead of the visit of former boss Andre Villas-Boas.
"It wasn't perfect because we've got an injury to Marco which is a little bit too early to be certain but it doesn't look good," Holland said.
"He'll have a scan tomorrow on the injury to his knee and his substitute Ramires had to go off with a muscular injury at the top of the hip in the gluteal area which was causing more discomfort as he tried to run it off.
"He'll be a major doubt for the Tottenham game at the weekend. They're the two major disappointments of the evening."
The double loss might be a blow to Chelsea manager Jose Mouirnho but the Portuguese boss has a wealth of options in midfield ahead of the London derby against Tottenham, with Frank Lampard now likely to partner John Obi Mikel from the start this weekend.
Fernando Torres meanwhile turned in a man-of-the-match display to see off Swindon and book a place in the fourth round, scoring the first after Robins stopper Wes Foderingham parried Juan Mata's shot before his turn and pass set up Ramires for the second.
And Holland was keen to lavish praise on the Spaniard, one of the positives from an unsettling evening in Wiltshire.
"He has threatened the goal, got the goal and had maybe three other chances, so he got in good positions and worked very hard for the team all night, which is the standard we're looking for across every position," the Chelsea assistant added.
"Whenever you have a game in training and you speak to a midfielder or defender in a five-a-side, they don't know the score, you ask a striker and he knows, and he knows how many he has scored.
"It's part of their DNA, I'm sure they're all the same, they want to score goals and it's ultimately how they're assessed so I'm sure from that point of view I'm sure Fernando is delighted but his contribution in all aspects was very good."