Four people believed to be from the same family were killed in an horrific crash on the A44 in Wales involving a tanker, car and a van.
A baby girl remains in a serious condition at the University Hospital of Wales Cardiff.
The family of five from the Llanidloes area were travelling in the same car when it collided with the fuel tanker east of Aberystwyth, on Tuesday afternoon.
The road was re-opened at 2.20am this morning.
The family's next of kin have been informed.
Dyfed-Powys Police are continuing their investigations.
Eluned Thomas, who lives on a farm two miles from the crash scene rang emergency services after a woman alerted her to a "very, very bad accident".
She said: "The woman said a fuel tanker was coming up from Llangurig and a car went straight into it."
A police spokesman said: "Dyfed-Powys Police remain at the scene of a serious RTC on the A44 between Llangurig and Ponterwyd.
"The collision occurred at approximately 2.55pm this afternoon (Tues), and a tanker, a car and a van were involved.
"We can now confirm that tragically two men and two women sustained fatal injuries in the collision, and a female infant has been taken to the University Hospital of Wales Cardiff in a serious condition.
"Next of kin have been informed and are being supported by specialist officers."