Danny Care will start at scrum-half and Joe Marler at loosehead prop for England's Six Nations opener against Scotland on 6 February. New coach Eddie Jones has preferred Care ahead of Ben Youngs, while Marler has been selected ahead of Mako Vunipola.
Elsewhere, Jones has selected the uncapped trio of Jack Clifford, prop Paul Hill and centre Ollie Devoto on the bench for the game at Murrayfield. Courtney Lawes has been named among the replacements after passing a fitness test on his hamstring.
"There were some tight calls on selection, but we have picked a match-day squad with a blend of experience and youth," Jones said, according to EnglandRugby.com.
"The boys have worked hard since coming into camp to understand how I want the team to play going forward. We have prepared well and I am pleased with the progress the group has made in the short time we've had together."
Jones, 56, admitted he is expecting a baptism of fire in his first Six Nations game. "We are confident we can go to Edinburgh and win, but we're in no doubt it will be a huge challenge," he said. "Playing at Murrayfield in front of a passionate Scottish crowd will be a real test for this team but one I know we can rise to."
Meanwhile, the Australian thanked his predecessor Stuart Lancaster and revealed he is looking forward to working with the array of talent in his squad during the Six Nations. "We are indebted to the work Stuart Lancaster has done over last four years. I have inherited a talented and highly motivated group of players," he explained.
Jones also named three vice-captains in Owen Farrell, Mike Brown and Billy Vunipola, all of whom will offer support to the newly appointed Dylan Hartley. "We have named three vice captains in Owen Farrell, Billy Vunipola and Mike Brown who will support Dylan Hartley with his leadership responsibilities," he said.
England: Joe Marler, Dylan Hartley (captain), Dan Cole, Joe Launchbury, George Kruis, Chris Robshaw, James Haskell, Mako Vunipola, Danny Care, George Ford, Jack Nowell, Owen Farrell, Jonathan Joseph, Anthony Watson and Mike Brown.
Replacements: Jamie George, Mako Vunipola, Paul Hill, Courtney Lawes, Jack Clifford, Ben Youngs, Alex Goode and Ollie Devoto.