All seven people on board a single-plane engine are said to have been killed after it crashed on a golf course.
The plane burst into flames upon impact, according to Hector Olivo from the Civil Aviation Institute.
The Piper PA-32 had just taken off from Punta Cana airport in the eastern tip of the Dominican Republic on an internal flight.
Punta Cana Civil Defense director Victoriano Guzman told Domincan Today that the plane tried to make an emergency landing in the golf course at Cocotal.
Punta Cana Airport's tower reported it had lost contact with the plane once it took off.
A Foreign and Commonwealth Office spokesperson said: "We are looking into reports of an incident involving a light aircraft in the Punta Cana region of the Dominican Republic.
"The British Embassy in Santo Domingo is liaising with local authorities to urgently gather more information and stands ready to offer consular assistance if required."
The bodies of six passengers and the pilot, which have yet to be formally identified, remain at the scene.
Local police said four of those on board were Spanish tourists and two were British. The pilot was from the Dominican Republic.
Civil aviation officials are investigating the cause of the plane crash.