Manchester United will begin their Europa League campaign against Danish side FC Midtjylland in the round of 32. Louis van Gaal's side avoided the likes of Borussia Dortmund and defending champions Sevilla, as did Liverpool, who face ties home and away against Bundesliga outfit FC Augsburg.
Tottenham Hotspur, however, face a replay of their fixture at this stage of the competition last year against Fiorentina. The Serie A club held Mauricio Pochettino's side to a 1-1 draw at White Hart Lane, before sealing a 2-0 win in the return leg in Florence to eliminate the north Londoners.
Elsewhere, Sevilla have been drawn against Ole Gunnar Solskjaer's side Molde, while Borussia Dortmund will meet Porto in what is arguably the tie of the round.
First leg ties will commence on Thursday 18 February with the second to follow a week later on 25 February. The draw for the last 16 stage will follow on 26 February.
Europa League round of 32 in full:
Saint-Etienne vs FC Basel
Villarreal vs Napoli
Sporting Lisbon vs Bayer Leverkusen
Sevilla vs Molde
Marseille vs Athletic Bilbao
Shakhtar Donetsk vs Schalke
FC Sion vs Braga
Galatasaray vs Lazio
Sparta Prague vs FC Krasnodar
Augsburg vs LIVERPOOL
Midtjylland vs MANCHESTER UNITED
Anderlecht vs Olympiakos
Fenerbahce vs Lokomotiv Moscow
Borussia Dortmund vs Porto
Fiorentina vs TOTTENHAM HOTSPUR
Valencia vs Rapid Vienna