Arsenal could face West Bromwich Albion in the Premier League this weekend without 11 first team players after Yaya Sanogo became the latest addition to the club's growing injury list.
The French forward netted his first Gunners goal in the victory over Borussia Dortmund in the Champions League but went off after 79 minutes with a hamstring injury and was replaced by Lukas Podolski.
Sanogo will therefore miss the trip to The Hawthorns this weekend, joining Mikel Arteta on the side-lines while Wojciech Szczesny and Danny Welbeck are also doubtful after missing the win over Dortmund.
The quartet join the already injured Mathieu Debuchy, David Ospina, Abou Diaby, Mesut Ozil, Theo Walcott, Serge Gnabry and Jack Wilshere on an extensive Arsenal injury list which threatens to further derail an uncertain campaign at the club.
On Welbeck, Wenger said: "He had a swollen knee so he wasn't available for Dortmund. We have been unlucky with injuries. What can you do about it? Not a lot.
"[Walcott] has a groin problem that he came back from England with. He's not available
The most serious injury to befall Arsenal during the last is the ankle ligament damage suffered by Wilshere which will keep the player out until early March after the England international underwent surgery on Thursday.
"He loves the game but he has also learnt to deal with adversity at a young age," he said. "He's determined. He deals very well with tackles and kicks but nobody would've dealt with that tackle. His injury is a consequence of a very bad tackle that was not malicious."
The Frenchman has also addressed the future of striker Podolski, who has made just one start in all competitions this season and has constantly complained over his lack of opportunities.
Wenger has stated Podolski is not for sale, and speaking on Friday he said: "He faces big competition. He has an outstanding attitude and he works very hard. I have had no enquiries from anybody."
The Arsenal boss also denied the club have any interest in signing out-of-favour Chelsea goalkeeper Petr Cech.