Angel di Maria
Di Maria had an X-ray following Portugal defeat.Getty Images/OLI SCARFF

Manchester United have suffered two more injury scares ahead of their Premier League clash with Arsenal after Angel di Maria and Luke Shaw suffered knocks on international duty.

With an already lengthy injury list to contend with, Louis van Gaal watched on as the club's record signing di Maria hobbled off after being trod on by Nani, whom the Dutchman allowed to leave the club on a season-long loan in the summer.

The 26-year-old returned after some brief treatment before he was replaced on the hour.

Argentina manager Gerardo Martino confirmed after the match the player will undergo an X-ray in order to determine the severity of the problem after what he described as a 'tough knock.'

"We don't think it's anything serious. It was quite a tough blow he took. It was a tough knock. It cut the skin a bit," Martino said after his side's 1-0 defeat to Portugal at Old Trafford, the Guardian report.

"But we have had a look and are evaluating the situation. We are looking at some x-rays, some images we took, but in spite of that we do not think it's too serious."

Di Maria added: "It was just a blow. I hope it doesn't swell any more so I can play at the weekend."

£27m signing Shaw also suffered a minor groin strain in England's 3-1 win over Scotland at Celtic Park and was replaced after 66 minutes by Kieran Gibbs.

Manager Roy Hodgson later confirmed his decision to replace the 19-year-old was a precaution, but the knock could yet affect his preparation ahead of Saturday.

United travel to the Emirates Stadium with up to ten players potentially unavaliable. Van Gaal suggested last week the quartet of Rafael da Silva, Jonny Evans, Phil Jones and Radamel Falcao may be fit enough to return to the bench but are unlikely to start against Arsene Wenger's side.

Daley Blind was the latest injury victim during the international break, suffering a knee injury while playing for Netherlands while David de Gea suffered a fractured finger last Friday that ruled him out of Spain's Euro 2016 qualifier against Belarus on Saturday.