Marc Marquez came to winning ways at the previous race in Germany, and he now arrives at one, where he has dominated in the last couple of seasons.
Valentino Rossi and Jorge Lorenzo will continue their Riders' World championship battle, with the Spaniard 13 points behind his teammate with eight races to go.
Where to watch live
The first practice session of the Indianapolis MotoGP starts at 3pm BST, with BT Sport 2 and BT Sports 2 HD providing live coverage in the UK.
Live coverage of the second practice session starts at 7pm BST. Real-time internet updates are available on MotoGP's official website.
- Circuit Name: Indianapolis Motor Speedway
- First MotoGP Race: 2008
- Circuit Length: 4.2km
- Number Of Laps: 27
- Race Distance: 112.6km
- Most Wins: Marc Marquez (1)
- 2014 Winner: Marc Marquez (Honda)
- 2014 Pole: Marc Marquez (Honda)
Riders' Championship review
Valentino Rossi (179) has increased the gap with Jorge Lorenzo (166) to 13 points following a podium place at the previous race in Germany, but with eight races to go, the battle is set to go down to the wire between the two Yamaha riders.
Marc Marquez (114) came back to winning ways in the previous race, but the reigning world champion is 65 points behind the leader, and will have to pull off a miracle to win the title again this year.
The Ducati's who enjoyed a great start to the season, are struggling to maintain the pace with the two factory teams, but Andrea Iannone (118) is ahead of Marquez in third with some consistent performances in the last four races.