Alderweireld, 27, has missed the club's last nine games due to a knee injury suffered in the 1-1 draw with West Brom in mid-October. The Belgium international's presence at the back has been greatly missed in that period, with Spurs having won just one game in his absence – a game where they shipped two goals at home in the 3-2 win over West Ham United.
A return could beckon on Saturday, however, with Mauricio Pochettino telling a press conference on Thursday: "Toby has been training with the team this week. We need to assess him tomorrow to see if he is ready or not."
Concern remains however over the fitness of Lamela. The Argentina international has been sidelined with a hip problem with his absence in the club's last six games also contributing to their frustrating run of form.
Pochettino confirmed the former Roma star is still unavailable while Ben Davies, who picked up an ankle injury during November's international break, also remains out.
Danny Rose however is available once again for the visit of Bob Bradley's side having served a one-match suspension in the 2-1 defeat at Chelsea.
There was more good news on Thursday morning after Spurs confirmed striker Harry Kane has penned a new contract until 2022.
The 23-year-old signed a new deal with Spurs just last year, but amid reported interest from Manchester United, the north London club have offered him an improved deal worth £125,000 a week, according to The Guardian.