Tom Croft and Christian Day have been added to England's Six Nations training squad following the latest spate of injuries to rock head coach Stuart Lancaster's plans.
Flanker Tom Wood injured his ankle in Northampton's weekend defeat to Racing Metro while Leicester lock Geoff Parling was forced off after just three minutes in the European Champions Cup defeat to Ulster.
Leicester flanker Croft and the uncapped Day step in with Lancaster also waiting to learn the extent of Owen Farrell's knee problem, with the Saracens fly-half awaiting a scan after suffering a knock in the defeat to Clermont on Sunday 25 January.
Kyle Eastmond was another to come out of the weekend with a fresh problem after suffering a shoulder knock in the victory over Glasgow Warriors.
Farrell will see a specialist in the evening on Monday 26 January, while Lancaster expects to received further updates on his stricken squad on 27 January.
"The players will be fully assessed once they get into camp and it's too early to give any definitive news on their status," he said.
England are already reeling from the losses of Courtney Lawes (ankle), Manu Tuilagi (groin) Joe Launchbury (neck) and Ben Morgan (broken leg).
Lancaster's side begin their Six Nations campaign against Wales in Cardiff on 6 February.