Stuart Lancaster has made five changes to his England side for Saturday's clash with Samoa at Twickenham.
Bath fly-half George Ford will make his first Test start, coming in for the injured Kyle Eastmond who suffered a concussion in last week's 28-31 defeat to South Africa.
Ford will take the no 10 shirt, a move which sees Saracens fly-half Owen Farrell move to inside centre.
Hooker Dylan Hartley drops to the bench with Rob Webber replacing him, while Ben Youngs comes in for Danny Care at scrum half.
There are two further changes in the back row as James Haskell and Ben Morgan come in to replace Tom Wood and Billy Vunipola.
On his decision to select Ford ahead of Farrell at fly-half, Lancaster told Sky Sports News: "It's great to give George a start in this series, having missed the summer tour through injury. He has been impressive in camp and now fully up to speed with the game plan and he is ready to run the game.
"Owen switches to 12 and I am sure will support George well. In the back row both James and Ben have been in great form and I am sure they will bring their physical presence to the game."
Following last Saturday's defeat, England are without a win in their last five games.
England team to face Samoa:
Mike Brown, Anthony Watson, Brad Barritt, Owen Farrell, Jonny May, George Ford, Ben Youngs, Joe Marler, Rob Webber, David Wilson, Dave Attwood, Courtney Lawes, James Haskell, Chris Robshaw (c), Ben Morgan.
Replacements:Dylan Hartley, Matt Mullan, Kieran, Brookes, George Kruis, Tom Wood, Richard Wigglesworth, Billy Twelvetrees, Marland Yarde