The Queen musical We Will Rock You will be closing its doors after 12 years.
The show, which is one of 10 longest-running musicals in West End, will be having its final curtain call on June 1. It would have performed at the Dominion Theatre 4,600 times by the time it closes.
Its creators, Brian May, Roger Taylor and Ben Elton, said: "We want to thank every one of the many hundreds of incredible musical theatre artists, musicians and crew with whom we've had the privilege of working at the Dominion since 2002.
"And of course the incredible audiences who have rewarded them with over four and a half thousand standing ovations."
The show is based around Queen's repertoire including Bohemian Rhapsody, Radio Ga Ga and Another One Bites the Dust.
Critics panned the show when it opened in 2002. The Mirror reported: "Ben Elton should be shot." The Guardian described the plot as "sixth form as it sounds".
But the show has been seen by more than 16 million people in 28 countries and is the longest ever show to have run at the Dominion.
The theatre's general manager, David Pearson, said: "It has been a privilege to have hosted We Will Rock You for the past 12 years.
"To have the show rocking the Dominion and seeing a standing ovation night after night has been quite amazing.
"We wish the show every success for the future, as we now prepare to accelerate our restoration and refurbishment programme ready to welcome an exciting new production in 2015."