For all Tuesday's Champions League goals and reaction join us here throughout the evening for LIVE coverage.
AC Milan have a daunting task in their hands as they travel to Estadio Vicente Calderón to overturn a 1-0 deficit which they succumbed to owing to a late Diego Costa header at the San Siro.
Where to Watch Live
Kick-off is set for 7:45pm GMT. Live coverage will be available on Sky Sports 1 and Sky Sports 1 HD.
Atletico Madrid are favourites coming into the tie, having displayed their menace in Italy in the previous fixture. Diego Simeone's side came away victorious and will look to press the advantage in Spain from where they can book their entry into the quarter finals.
The Spaniards are a shock addition to the La Liga title race, currently second behind Real Madrid after a convincing 2-0 win over Celta Vigo.
Atletico's form in the Champions League is down to the prolificacy of Costa, who has scored five goals this far and will be available against Milan after serving a suspension. With Real Madrid and Barcelona favourites to move to the quarters, Atletico will be looking to make it a threesome with a splendid performance.
AC Milan have been in diabolical form this season and will be looking to put their league form behind them and come into the tournament with a fresh desire and try to pull off an upset against the inform Spanish team.
New manager Clarence Seedorf has failed to lift his squad following the departure of Massimiliano Allegri and managed to secure only 13 points from a possible 24.
They come into the game on the back of a disappointing 1-0 defeat at the hands of Udinese. However, the likes of Kaka and Abel Tarabbt should be back to face Atletico, which will give them some much needed boost ahead of a tough fixture.
What the Managers Say
Diego Simeone: "We have to contain and control the game. The clash will depend on the intensity we produce in the midfield. An open game will better suit Milan. They are an attacking team given the characteristics of their players. We need to make the most of the space they give us."
Clarence Seedorf: "We need to continue working hard, believing that we're on the right track ahead of Tuesday. We'll give our responses out on the pitch. I'm not worried. We need to think positive and be optimistic. We need to be convinced about our abilities to give a good performance and turn the situation around."
- Last Five(all competitions, most recent first): W D L W W
- Last Result: Celta Vuigo 0--2 Atletico Madrid
- Last Five(all competitions, most recent first): L L W L W
- Last Result: Udinese 1-0 AC Milan