Matteo Darmian and Daley Blind struggled in Manchester United's Carabao Cup defeat to Bristol City on Wednesday. The duo have not travelled with the squad to face Foxes.
Mkhitaryan enjoyed an explosive start to the season, laying on five assists for his teammates in the opening three matches of the season.
Jose Mourinho has labelled Bristol City "lucky" after watching his Manchester United side be knocked out by the Championship side at Ashton Gate.
Marouane Fellaini suffered a medial knee ligament injury while in action for Belgium in October. He has been struggling with the knee injury and is currently on the sidelines.
Jose Mourinho hints Henrikh Mkhitaryan could be back in Manchester United squad to face Bristol City
Henrikh Mkhitaryan has struggled to impress in recent months and his dip in form has forced Jose Mourinho to drop him from Manchester United's squad in the last few matches.
Bordeaux insist they do not want to sell Brazilian starlet Malcom during the January transfer window amid talk of an imminent bid from Manchester United.
City are 11 points clear of their local rivals after 18 matches, setting a new English top-flight record of 16 successive wins in the process.
United boss Jose Mourinho has hinted that he could let Mkhitaryan leave the club in January after growing frustrated with his poor form.
Bristol City fans can inspire the club to another win over Premier League opposition when Manchester United visit Ashton Gate in the Carabao Cup, according to Lee Johnson.
Antonio Valencia limped off after 66 minutes of Manchester United's 2-1 win over West Brom on Sunday after suffering what Jose Mourinho labelled as a "December injury".
Malcom indicated an interest in moving to Manchester United this summer, and he could still move with Mourinho plotting a winter move.
Manchester United have been given the green light to pursue a £60m deal for Alex Sandro in the January transfer window, with Juventus said to be open to offers.
Mourinho confirms Antonio Valencia's injury after West Brom win and defends Lukaku's lack of celebration
Antonio Valencia came off with a hamstring injury after 66 minutes during Manchester United's win over West Brom.
United are 14 points behind Manchester City heading into their clash against West Brom at the Hawthorns.
Pardew says he prefers Mourinho to Guardiola due to the Red Devils boss's knack for winning trophies.
Henrikh Mkhitaryan has been left out of United's 18-man squad for seven of their last eight matches and is out of favour at the club.
Arsene Wenger saw his Arsenal suffer a 3-1 defeat against Manchester United, despite dominating the majority of the game at home.
Mateu Alemany has confirmed a decision whether Andreas Pereira will be allowed to continue at Valencia after January will be taken by the player and Manchester United United.
Manchester United ready to sanction Henrikh Mkhitaryan's sale and replace him with Arsenal star Mesut Ozil
Manchester United's Henrikh Mkhitaryan has not made it to the squad in seven out of the last eight games played in all competitions.
Jose Mourinho has claimed that Manchester United are open to making signings in January despite not being a fan of the winger market.
Manchester United and Barcelona target Antoine Griezmann allowed to leave Atletico says Diego Simeone
Antoine Griezmann is wanted by both Manchester United and Barcelona, with the Camp Nou outfit leading the chase for the France international's services.
Mata says United will try to keep picking up wins and stay within touching distance of league leaders Manchester City.
Manchester United injury news: Jose Mourinho coy on whether or not Eric Bailly's season could be over
Eric Bailly has made eight starts in the Premier League for Manchester United this season and the Red Devils conceded only three goals in the process.
Mkhitaryan has been left out in the cold by Mourinho in recent weeks and is said to be of interest to Inter boss Luciano Spalletti.
Manchester United manager Jose Mourinho says his other attacking options are more deserving of a first-team role than Henrikh Mkhitaryan.
Angel Gomes committed his future at Manchester United after the youngster put pen to paper to sign his first professional contract with the club.
Scott McTominay committed his future to Manchester United after signing a new four-year deal in October.
Ozil, 29, is in the final six months of his Gunners contract, with talks over a new £235,000-a-week deal having ended in failure.
Bailly has missed United's last eight matches and has shown little improvement in his recovery so far.
Mourinho took offence at City's celebrations after their 2-1 win over United at Old Trafford on 10 December.