England Test captain Alastair Cook is one of five big names to be left out of the squad to face Australia in the upcoming one-day series after their exertions in the recently concluded Ashes series.
James Anderson, Ian Bell, Stuart Broad and Graeme Swann have also been rested after helping England claim a 3-0 series victory over Australia.
With the return series starting in November, the England management team have made the decision to hand the influential players a rest, as confirmed by national selector Geoff Miller.
"Following a very intense period of cricket this summer we have decided to rest a number of senior players which will allow them to recover from a heavy workload over the last three months and to prepare for the tour of Australia, which begins in eight weeks," Miller told the ECB website.
"This creates an excellent opportunity for players who have impressed in county cricket and for England Lions recently to test themselves at international level as we continue to build a squad ahead of the ICC Cricket World Cup, which is less than 18 months away.
"There are a number of very experienced one-day players in the squad alongside players who are new to international cricket and we are expecting a very tough challenge both from a strong Ireland side and then from Australia in what will no doubt be a very competitive series."
Eoin Morgan will captain the side, while uncapped quartet Michael Carberry, Chris Jordan, Boyd Rankin and Jamie Overton were also named in the squad.
England plat two Twenty20 games against Australia later this month before travelling to Ireland to play their first ODI on 3 September.
Joe Root, Kevin Pietersen and Jonathon Trott will all miss the trip to Ireland but will return for the five-match ODI series against Australia which begins on 6 September.
England ODI squad v Ireland:
Eoin Morgan (Middlesex, capt), Gary Ballance (Yorkshire), Ravi Bopara (Essex), Danny Briggs (Hampshire), Jos Buttler (Somerset, wkt), Michael Carberry (Hampshire), Steven Finn (Middlesex), Chris Jordan (Sussex), Jamie Overton (Somerset), Boyd Rankin (Warwickshire), Ben Stokes (Durham), James Taylor (Nottinghamshire), James Tredwell (Kent), Luke Wright (Sussex)
England ODI squad to play Australia:
Eoin Morgan (Middlesex, capt), Ravi Bopara (Essex), Jos Buttler (Somerset, wkt), Michael Carberry (Hampshire), Steven Finn (Middlesex), Chris Jordan (Sussex), Jamie Overton (Somerset), Kevin Pietersen (Surrey), Boyd Rankin (Warwickshire), Joe Root (Yorkshire), Ben Stokes (Durham), James Tredwell (Kent), Jonathan Trott (Warwickshire), Luke Wright (Sussex)