Honda's Marc Marquez who is the defending champion, having won the San Marino Grand Prix last year, comes into this race as leader in the riders championship standings and is the favourite to win this year as well. Maverick Vinales who won the British Grand Prix last week will look to continue his form and cause another upset.
Where to Watch Live
The first practice session of the Indianapolis MotoGP starts at 8:55am BST, with BT Sport 2 and BT Sports 2 HD providing live coverage in the UK.
Live coverage of the second practice session starts at 1:05pm BST. Real-time internet updates are available on MotoGP's official website.
- Circuit Name: Misano Adriatico
- First MotoGP Race: 1981
- Circuit Length: 4.2km
- Race Distance: 118.3km
- Most Wins: Valentino Rossi and Jorge Lorenzo (3)
- 2015Winner: Marc Marquez (Honda)
Rider's Championship Review
The 2016 MotoGP season has been both exciting and unpredictable with seven different riders winning the last seven races equalling the all-time record.
Honda's Marquez has established himself at the top of the riders standings with 210 points, 50 points clear of his nearest rival Valentino Rossi of Team Yamaha. Rossi's teammate, Lorenzo, rounds up the top three with 146 points.
Vinales who caused an upset to win the British Grand Prix last week, his maiden win in MotoGP, is in the fourth place with 125 points.
Out of the 12 races so far this year, nine have been won by the Yamaha duo of Rossi and Jorge Lorenzo. After last week's victory at Silverstone, the Italian rider is topping the championship leader board with 236 points.
Lorenzo is 12 points behind him in the second place. Marquez, on the other hand, is in the third place with 159 points, 77 points behind the championship leader.