The Saracens man becomes fourth player to miss entire Championship due to injury.
Geoff Parling and Tom Wood joined an ever-increasing injury list on Saturday.
Lancaster admits the core of his World Cup squad is cemented after announcing his Six Nations party.
Stuart Lancaster retains Chris Robshaw for Six Nations campaign ahead of opener against Wales.
Northampton lock doubtful for championship after confirmation he faces surgery on chipped ankle bone
The Saracens lock is free to play in Championship opener against Wales on 6 February
The Gloucester forward suffered the injury in Friday's win over Saracens.
Sale's Steve Diamond expects 27-year-old to leave for Toulon if again overlooked by Stuart Lancaster.
Northampton forward available for Wales clash after elbowing Leicester's Matt Smith
The hooker's second career red card against Leicester highlights the dilemma facing Stuart Lancaster.
The 23-year-old faces a rehabilitation process of three to four months.
The Sale fly-half is optimistic over being involved in the World Cup next autumn.
Reacting to successive defeats proves England can bounce back from adversity, says Robshaw
Lancaster defends England's lack of creativity and reliance on the scrum
Ben Morgan scores two tries as England end their autumn campaign with a much-needed win
England face Australia in the fourth QBE international series match of the autumn at Twickenham.
Gloucester centre will start with George Ford also retaining his place in the side.
The 21 year old Bath flay-half impresses the England coach
Ford scores 16 points on maiden start to down Samoa at Twickenham
England face Samoa in the second QBE international series match of the autumn at Twickenham
Owen Farrell moves to inside centre in England's reshuffled side.
Rugby union fly half Botica speaks exclusively to IBTimes TV in London
A report from EY says that the UK's economy could benefit by almost £1bn
Lancaster says philosophy will not deviate despite suffering a fifth straight defeat
A second straight autumn international defeat leaves England's World Cup hopes in tatters
England face South Africa in the second QBE international series match of the autumn at Twickenham
Welsh referee alleged to have been taunted from the stands at Twickenham on Saturday
New Zealand 'struggled to hold on' to England says the Northampton open-side
Lancaster says England will not change their philosophy despite suffering fourth defeat of 2014 to the All Blacks.
Richie McCaw and Charlie Faumuina's second half tries frustrate England