Angel Di Maria is set to makes his Manchester United debut against Burnley on Saturday 30 August after completing his £59.7m move from Real Madrid.
Asked if the British record signing would make an appearance at Turf Moor, United manager Louis van Gaal said: "I think he is ready to play."
The inclusion of Di Maria in the 18-man match-day squad will boost the Red Devils, who are still looking for the first win of the season after two losses and a draw.
Speaking at his weekly press conference, Van Gaal also said his beleaguered side will challenge for the Premier League title next season and be Champions League winners in three years.
He reiterated it will take three months for his players to realise his football philosophy but that, despite their poor start to the season, he still aims to guide them to a top-four finish.
"That process [of rebuilding United] needs time. We are building up a new team and I hope we will succeed," Van Gaal said.
"I hope we are in the top four this season because the Champions League suits a club like Manchester United. And then the next step is to be the champions and then the next step is to be the winners of the Champions League. That takes time."
Unveiling £59.7m signing Di Maria on Thursday 28 August, Van Gaal said the club would be active in the transfer market over the coming days.
The 63-year-old confirmed chief executive Ed Woodward has been busy hammering out deals at Old Trafford.
"I don't know about transfers between now and Monday because I am not the one who can choose," he explained.
"I give my opinion and the player can do what he wants with that opinion. Of course, I shall say which players I want [to sign] and which are better to leave but Ed [Woodward] is handling the transfer market. I don't interfere in that process."
Van Gaal said he could not compare the challenges he has faced with United to any other managerial post he has had but that the Old Trafford club was making progress.
He will be hoping United can get their season on track when they travel to Turf Moor for Saturday's early kick off.
When the sides last met in 2009, it was the Clarets that emerged victorious with a 1-0 win.