Sir Elton John is calling for a boycott of all Dolce and Gabbana products in protest at their comments they made about "synthetic" IVF-born children.
The singer, who has two children with his husband David Furnish, reacted angrily after the designers criticised same-sex families and the use of the IVF fertility treatment.
Speaking to Italian magazine Panorama Domenico Dolce and Stefano Gabbana – who were once a couple, but oppose same-sex marriage – also voiced their objection to gay adoption.
They said: "The only family is the traditional one. No chemical offsprings and rented uterus: life has a natural flow, there are things that should not be changed."
Dolce also said giving birth to children "must be an act of love", adding: "You are born to a mother and a father – or at least that's how it should be.
"I call children of chemistry, synthetic children. Uteri (for) rent, semen chosen from a catalogue."
John has now called for a total boycott of the fashion company in an Instagram post featuring a photo of the pair.
John wrote: "How dare you refer to my beautiful children as 'synthetic'.
"And shame on you for wagging you judgemental little fingers at IVF – a miracle that has allowed legions of loving people, both straight and gay, to fulfil their dream of having children.
"Your archaic thinking is out of step with the times, just like your fashions.
"I shall never wear Dolce and Gabbana ever again. #BoycottDolceGabbana."
Gabbana previously revealed in 2006 he asked a woman to be the mother of his child, but changed his mind because of his rejection of same-sex families.
"I am opposed to the idea of a child growing up with two gay parents," he said. "A child needs a mother and a father. I could not imagine my childhood without my mother. I also believe that it is cruel to take a baby away from its mother."