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Where to watch live
Kick-off is at 8pm BST. Live coverage of the match is on Sky Sports 1 and Sky Sports 1 HD. Radio commentary of the game is available on BBC Radio 5 Live.
Liverpool are off to a flyer this season and started the campaign on a bright note with a 4-3 win over Arsenal at the Emirates. Apart from the 2-0 defeat to Burnley and a point against Tottenham Hotspur at White Hart Lane, the Reds have won all their fixtures.
This also includes a 2-1 win over Antonio Conte's Chelsea in their own backyard and a dominating performance against Premier League champions Leicester City at home. It will be one year since Jurgen Klopp replaced Brendan Rodgers at Anfield.
Klopp will be looking for another three points when his side take on their arch-rivals in the league clash on Monday evening. The former Borussia Dortmund manager will be hoping his key players are fit to face the Red Devils.
United enter this fixture after settling for a 1-1 draw against Stoke City before the international break. Anthony Martial's second half goal was cancelled by former Liverpool midfielder, Joe Allen's late strike.
Jose Mourinho will be disappointed after his side failed to capitalise on United's dominant performance for three points. The former Real Madrid and Chelsea manager will be hoping to bounce back when his side travel to Merseyside.
United have three big domestic fixtures lined up, starting from their clash against Liverpool. They face Chelsea in the league, while hosting Manchester City in the EFL Cup fixture at Old Trafford after their trip to Stamford Bridge.
What managers say
Jurgen Klopp: "I don't care about how much money another club can spend. I don't think about it for one second of my life. Absolutely not. Having more money, or all the money in the world is not in my dreams for the manager's job. I have never thought about this. So I'm completely fine with this situation. I am completely fine with what we could spend and what we did spend — and that's was not nothing."
Jose Mourinho: "When you have the ball you want to score, you want to be dominant, you want the ball and this is what we are doing. We are playing the way we are playing, and we have to improve in many things. But we have a certain style of play and we are not going to change that."
Betting Odds (betfair)
- Liverpool: 6/5
- Draw: 12/5
- Manchester United: 13/5
Possible XI: Mignolet; Milner, Lovren, Matip, Clyne; Can, Henderson; Countinho, Firmino, Mane; Sturridge
Possible XI: De Gea; Valencia, Bailly, Smalling, Blind; Herrera, Pogba; Lingard, Mata, Rashford; Ibrahimovic.