Nate Diaz is reportedly interested in making a long-awaited return to the octagon and fill in for Max Holloway at UFC 222.

Holloway was set to defend his featherweight title against Frankie Edgar as the pay-per-view's headliner on 3 March in Las Vegas in what would be his second title defence.

However, a leg injury recently ruled the Hawaiian out of the bout, marking the second time a fight between him and Edgar had to be cancelled.

It comes as a big blow for the promotion who have already suffered from various withdrawals in recent weeks and have little time to schedule a new marquee main event.

However, according to Lance Pugmire of the Los Angeles Times, Diaz is ready to give the UFC a helping hand by offering to step in for Holloway, though it is not clear whether he will be fighting former lightweight champion Edgar or a different opponent.

"The best option to fill in for the Max Holloway void at UFC 222 is Nate Diaz and he tells me he's 100% interested," Pugmire wrote on Twitter. "Make it happen, UFC."

Diaz last fought in a majority decision loss to Conor McGregor during their rematch at UFC 202 in August 2016, earning a huge payday in the process.

Having maintained that he will only return to fight a big name or in a bout that would earn him $20m (£14.2m), the 32-year-old did not look likely to compete anytime soon until a recent post on social media hinting at a return.

The development led to lightweight contenders in Eddie Alvarez and Kevin Lee calling out the Stockton fighter for a potential meeting, which could ideally serve as a new main event for UFC 222, though there is nothing confirmed at this stage.

Meanwhile, McGregor has taken a jab at Holloway for pulling out of the main event by posting an image of their fight back in 2013.

When there is no referee to save you.

A post shared by Conor McGregor Official (@thenotoriousmma) on

The duo have gone back and forth in recent months leading to speculation about a potential rematch and it has only continued with "Blessed" returning fire on Twitter.