Eddie Jones has made three changes to his England side ahead of their Six Nations clash on 14 February. Courtney Lawes replaces Joe Launchbury at lock while loose-head prop Mako Vunipola and scrum-half Ben Youngs come in for Joe Marler and Danny Care.
Saracens forward Maro Itoje, 21, could make his debut at the Stadio Olimpico after being named on the bench with Paul Hill. Ollie Devot meanwhile has dropped out of the 23-man squad.
After beating Scotland 15-9 in their opening game, Jones feels the necessary changes have been made ahead of their trip to the Italian capital. "Mako, Ben and Courtney have been pushing hard for selection during training, but they also fit the game plan we want to implement against Italy," he said. "Danny, Joe Marler and Joe Launchbury will all have significant roles to play to finish the game.
"It has been an intense week of training and I am pleased with how the group have responded to some of the things we've asked them to do. Maro has consistently impressed me this week and, together with his excellent club form, has deserved his call up to the match day squad.
"We are confident we can go to Rome and win but we're in no doubt of the challenge we face. Italy took France very close last weekend in Paris so they'll be fired up."
England squad to face Italy
1. Mako Vunipola, 2. Dylan Hartley, 3. Dan Cole, 4. Courtney Lawes, 5. George Kruis, 6. Chris Robshaw, 7. James Haskell, 8. Billy Vunipola, 9. Ben Youngs, 10. George Ford, 11. Jack Nowell, 12. Owen Farrell, 13. Jonathan Joseph, 14. Anthony Watson, 15. Mike Brown
Replacements: 16. Jamie George, 17 Joe Marler, 18. Paul Hill, 19. Joe Launchbury, 20 Maro Itoje, 21. Jack Clifford, 22. Danny Care, 23. Alex Goode