Manchester United Under-21 coach Warren Joyce expects a number of the club's young players to leave on loan before the start of the new season.
Jesse Lingard, Ben Pearson, Sam Johnstone and Will Keane were among the United youngsters to enjoy spells in the Championship and League One last year, with the latter already sealing another move away, having joined Preston North End on a season-long loan deal.
Johnstone and Lingard have were named in United's pre-season tour squad on Monday alongside fellow academy graduate Sean Goss, who will get his first taste of first team experience on the trip.
Goss, 20, could be in line for a loan move following the tour the of the US, with Joyce expecting some of his Under-21 Premier League-winning midfielders to leave for first team opportunities at a higher level.
"Possibly, for one or two of the midfield player, it is their time," Joyce told United's official website. "We have never stopped lads going out even if it does leave us badly short. They have got to go out and play men's football at a higher level and prove if they are good enough to come back to Manchester United or prove they can have a career at Championship level or above."
Keane has already left the club in what is his fourth spell away from Old Trafford since making his first team debut in 2011.
"Will is chomping at the bit to go and prove himself in league football," Joyce said. "Even though the stats might not show it, he did pretty well at a Sheffield Wednesday side that was up and down.
"His overall performance was really good. He scored one or two goals and was a bit unlucky to get an ankle injury when he was doing particularly well. He's got a year to make a name for himself."