Where to watch live
Kick-off is at 12.30pm BST. Live coverage of the match is on BT Sport 1. Catch the highlights on Match of the Day 2 on BBC One and BBC One HD at 10.30pm BST.
United come into this fixture after registering a narrow 1-0 victory over Zorya Luhansk in the Europa League fixture. This was their first win in this season's Europa competition, following their 1-0 defeat to Feyenoord in the opening fixture.
Zlatan Ibrahimovic scored the only goal of the match against the Ukranian outfit to keep his side's winning momentum intact. In the last league tie, Jose Mourinho saw his side register a comfortable 4-1 victory over Leicester City.
United had four different players on the scoresheet, including that of Paul Pogba. The France international, who rejoined the Red Devils in the summer scored his first goal for his side against the Foxes.
Stoke have struggled since the start of the 2016/17 season as they are in search of their first league win of this campaign. They settled for a 1-1 draw against Middlesbrough in the opening match and also in the last tie against West Bromwich Albion, which saw them collect two points out of six matches.
Mark Hughes also saw his side suffer a 2-1 defeat to Hull City in the third round of the league cup. They will be keen on bouncing back when they face United as they are searching for their first three points of this season.
In the six league matches they have played, Stoke have conceded 15 goals and scored five in the process.
What managers say
Jose Mourinho: "I need time. I need the players to play, I need to see them in different circumstances, I need to understand more about them. There are so many and so much to learn about the players that only when you work with them for a long, long time you know them well. There is always a surprise behind the door when you work with the team for three, four or five months."
Mark Hughes: "They have addressed some of their failings from last year with some very big signings. You can see the club's intent in what they have done this summer. It is maybe a little bit of a transitional period that they are going through, but you sense that there will be a marked improvement on where they finish this season."
Betting Odds (betfair)
- Manchester United: 1/3
- Draw: 9/2
- Stoke City: 10
Possible XI: De Gea; Valencia, Smalling, Baily, Blind; Herrera, Pogba; Rashford, Mata, Martial; Ibrahimovic
Possible XI: Given; Johnson, Shawcross, Bruno, Pieters; Cameron, Whelan; Shaqiri, Bojan, Arnautovic; Bony.