Following news of Angelina Jolie and Brad Pitt's imminent divorce, the question on everyone's lips is 'what led to the demise of one Hollywood's highest profile marriage?' Insiders tell TMZ that the Maleficent actress finally threw in the towel after growing "fed up" with her other half's alleged marijuana consumption and alcohol use, feared that his "anger problem" would affect their six children.

According to TMZ, Jolie, 41, cited irreconcilable differences and is seeking physical custody of Maddox, 14; Pax, 12; Zahara, 11; Shiloh, nine, and seven-year-old twins Vivienne and Knox. Although the Tomb Raider star has declined to comment on the split, her lawyer Robert Offer told the BBC that the "decision was made for the health of the family".

The A-listers fell in love on the set of 2005 action movie Mr. & Mrs. Smith, and tied the knot in August 2014 in a private ceremony in the south of France, surrounded by close family and friends.

According to The Sun, the writing has been on the wall for Brangelina for months, with the pair living separate lives. "There have been rumours around the status of the relationship for years, but they are now very much in turmoil and it is hard to see a way out," a source said. "There have been a constant string of arguments about their future and their children."

The insider added: "They ended up completely disagreeing over how to raise the kids."

Pitt made no secret of his love of weed at the height of the career. Back in 2010, he told Hollywood Reporter magazine that he hated the person he became as a result of his drug use. "I got really sick of myself at the end of the 1990s," he told. "I was hiding out from the celebrity thing, I was smoking way too much dope, I was sitting on the couch and just turning into a doughnut and I really got irritated with myself."

In 2012, he revealed that becoming a father was all the motivation he needed to finally kick the habit completely. "I'm a dad now. You want to be alert and my eyes used to glaze over when I did that," he said.

Aside from clashing over how to raise their children there are suggestions that their close working relationship may have ultimately caused a rift between the couple.

In 2015 Jolie opened up about the impact during a candid sit-down with NBC's Tom Brokaw while promoting their romantic drama film, By the Sea. It was her second time she had helmed a big screen a big screen movie and second time she's directed her husband.

"Brad and I have our issues, but if the characters were even remotely close to our problems we couldn't have made the film," she said at the time. "To be clear: we have fights and problems like any other couple.

"We have days when we drive each other absolutely mad and want space, but the problems in the movie aren't our specific problems."

Unfortunately their on-screen chemistry was not enough to salvage the widely-panned movie about a tempestuous marriage. It bombed at the box office and made only $3.3million (£2.5m). It was a drop in the ocean compared to £300million Mr and Mrs Smith, the first film they appeared in together.

Brad Pitt Angelina Jolie
Angelina Jolie and actor Brad Pitt have filed for divorce after two years of marriage. Mario Anzuoni/Reuters