Saturday, 13 August
Wigan Athletic v Norwich City
Kick off: 15.00 BST
Last season: N/A
Both sides look like early candidates for relegation and this opening fixture has all the hallmarks of a late-season "six-pointer".
Wigan have lost Charles N'Zogbia since narrowly avoiding relegation last term and Roberto Martinez's side are one of the favourites for the drop this season.
Similarly, Norwich look in danger of slipping straight down again. Manager Paul Lambert has brought in Everton's James Vaughan, Milwall's Steve Morison and Manchester United defender Ritchie De Laet but the Canaries could struggle if they don't pick up points from the teams around them.
Striker Hugo Rodallega is available for Wigan but Martinez is without midfielder James McCarthy (ankle) and defender Antolin Alcaraz (fatigue).
Live online/TV coverage
In the U.K., Sky Sports and ESPN will share live coverage and highlights, while Match of the Day will broadcast a comprehensive highlights program on Saturday and Sunday nights, full details are available on the BBC Web site. In the U.S., Fox Sports and ESPN will show select matches and highlights, check their individual TV schedules for further details.
Indian fans will have to contend with ESPN Star's coverage, full details are available on the company's website.
For all other countries, the official Premier League website has a comprehesive list of broadcasters. Further live online coverage of Saturday afternoon matches from around the world is available here.