Chelsea's goalless draw with La Liga leaders Atletico Madrid in the Champions League semi-final first leg was overshadowed with the loss of four players ahead of the return game at Stamford Bridge.
Petr Cech and captain John Terry have been ruled out of the remainder of the Premier League season with respective shoulder and foot injuries while both Frank Lampard and John Obi Mikel picked up second yellow cards ruling them out of the second leg.
Meanwhile, Samuel Eto'o's knee problem which forced him to miss the trip to Madrid and Eden Hazard's calf injury which has seen him absent for the last three weeks sees both players doubtful for both the Premier League trip to Liverpool and the visit of Diego Simeone's Atletico.
"Petr Cech's season is over," Chelsea manager Jose Mourinho said. "Don't ask me to explain it technically, but it's over. With John, we'll have to play in the final for him to play with us again."
Hazard did travel to Madrid but was omitted from the 18-man squad selected by Mourinho at the Vicente Calderon while, Eto'o, who has been often used at home this season didn't travel.
Branislav Ivanovic, suspended for the first leg, is expected to return next week as is Oscar who was an unused substitute in the Spanish capital on Tuesday night.
Mourinho faces a selection dilemma for the second leg visit of Atletico, with David Luiz likely to deputise for Terry in the centre of defence alongside Gary Cahill though Marc Schwarzer will continue in goal.
The loss of Lampard and Mikel means Ramires will feature in the centre of midfield potentially alongside long-term injury victim Marco van Ginkel who hasn't featured in the Chelsea first team since last September due to a knee injury. January signing Nemanja Matic is ineligible.
If Hazard and Eto'o fail to recover in time, Willian and Andre Schurrle will accompany either Fernando Torres or Demba Ba – Chelsea's match-winner against Paris Saint Germain in the quarter final – in attack.