Depay has barely featured for United this season while Januzaj has struggled at Sunderland.
Ivan Rakitic also back after being rested in 1-1 draw at Villarreal.
Mertesacker is yet to feature for Arsenal this season due to a knee injury.
Former Sweden captain missed EFL Cup win over Hull but manager confident he will return
Sevilla looking to overturn 3-0 deficit from first leg of Copa del Rey round of 16.
The 23-year-old has endured a turbulent couple of seasons at the Hawthorns.
Ibrahimovic and Pogba have been the two key players for United this season.
French international set to quit Old Trafford 18 months after he joined from Southampton.
Federer is currently ranked world number 17 going into the 2017 Australian Open.
Rosberg announced his retirement five days after winning the 2016 Formula One title.
Welbeck returned to action against Preston after 7 months on the sidelines.
Former Red Devils defender believes Jose Mourinho's side are still title contenders.
Southampton will leave Jose Fonte from the squad.
Rojo suffered a muscular problem in United's 4-0 win over Reading in the FA Cup.
Ozil is yet to play in 2017 after missing the last two weeks due to illness.
But the Belgium international admits move should only be attractive for older players.
Blues boss reportedly interested in Swansea's Fernando Llorente and West Ham's Michail Antonio.
Croatian international will need to cut his salary to join Luis Enrique's side.
Fifa's plans to expand the tournament have not been particularly well received.
Bayern Munich are also believed to be interested in the young forward.
Chelsea captain was dismissed during the second half of the 4-1 FA Cup win over Peterborough.
Old Trafford plays host to the first leg as Jose Mourinho's side face The Tigers
Paddy Lowe leaves three-time constructors' champions after three-and-a-half years with the team.
Oscar moved to Shanghai SIPG in a deal worth a staggering £60m.
Tony Cottee is hopeful the Belgium striker could be tempted into moving to the London Stadium.
Catalans host Basque side following a 2-1 defeat at San Mames.
Sergio Ramos also made his comeback on Monday.
Brazilian has been instrumental to Chelsea's title charge since returning from Paris Saint-Germain.
Gunners complete deal to pluck talented defender from the seventh tier of English football.
35-year-old resigned as his country's ODI and T20 captain last week.