Where to Watch
Kick-off is set for 7:45pm BST. There is no live coverage of the game but audio commentary will be available on tottenhamhotspur.com as well as live updates on BBC Radio 5 Live.
The north London side are currently in second, just seven points behind Antonio Conte's side and a win in Wales could be crucial with Chelsea hosting Manchester City at the same time.
Spurs are currently the most in-form side in the Premier League with 7 wins in their last 10 games, the most recent of which came in a 2-0 win at Burnley.
However, there are some fresh injury concerns for Mauricio Pochettino's side. Harry Winks is out for the season after injuring his ankle against Burnley while Victor Wanyama is also a doubt as he limped off.
Harry Kane, Danny Rose and Erik Lamela are all still unavailable, but Kyle Walker should return after being rested in the last league game.
While Palace's win over Chelsea was beneficial for Spurs, it was anything but for Swansea who are now three points behind Sam Allardyce's side in 17th place.
Despite a promising start under Paul Clement with five wins in his first eight games, the Swans are now winless in their last three games. They suffered a loss to fellow relegation candidates Hull City who are now just one point behind.
With a mere one point separating Swansea from the relegation zone, a win would be absolutely crucial for their Premier League survival hopes.
Fernando Llorente is still a doubt after an ankle injury saw him miss the 0-0 draw against Middlesbrough. However, Wayne Routledge should be back in the side after missing the last game due to personal reasons.
What Managers Say
Paul Clement: "They have been challenging for the last couple of seasons and Mauricio Pochettino has done a really good job. He has a good, young squad who play exciting football. The Chelsea result at the weekend has probably given them belief that they can take the title race right to the end of the season. I think it will be an interesting game for us. They will want to win here and we need points too," via BBC Sport.
Mauricio Pochettino: "We reduced the gap [against Chelsea] by three points but it's still a big gap, seven is a massive difference. For us it's about being focused and trying to improve on last season in terms of numbers. Nothing is impossible in football and that is our idea, our philosophy," via BBC Sport.
Betting Odds (Betfair)
- Swansea to win: 9/2
- Draw: 29/10
- Tottenham to win win: 7/10
Possible XI: Lloris; Walker, Dier, Vertonghen, Davies; Dier, Dembele; Son, Alli, Eriksen; Janssen.
Possible XI: Fabianski; Naughton, Fernandez, Mawson, Olsson; Cork, Fer; Routledge, Sigurdsson, Carroll; Ayew.