Roger Federer will hope to register his 225th grand slam win at the U.S. Open on Thursday, as he edges closer to an elusive 17th title.
The number three seed faces Israel's Dudi Sela in today's second round clash. A win will move him one clear of Andre Agassi in the overall standings and closer to Jimmy Connors's record of 223 career wins.
Federer should better that record sometime next year but first he has to overcome Sela.
"He's a talented little guy," Federer told Reuters.
"He really works well with his height. That's why you have to be careful that you don't underestimate a player like that."
World number one Novak Djokovic is also in action this afternoon, the Serb plays Argentina's Carlos Berlocq.
"This year has been tremendous, best so far in my career, and there has been a lot of talks about history-making and this incredible run," Djokovic said.
"I'm extremely honoured and privileged to be part of the elite of the players that have made the history of the sport but my main focus is on the court."
Order of play for Thursday 1 September, play starts at 11.00 [16.00 BST]
Arthur Ashe Stadium - 1100
Mirjana Lucic (CRO) v.  Francesca Schiavone (ITA)
 Roger Federer (SUI) v. Dudi Sela (ISR)
Michaella Krajicek (NED) v.  Serena Williams (USA)
Arthur Ashe Stadium - 1900
 Caroline Wozniacki (DEN) v. Arantxa Rus (NED)
 Novak Djokovic (SRB) v. Carlos Berlocq (ARG)
Louis Armstrong Stadium - 1100
 Jelena Jankovic (SRB) v. Jelena Dokic (AUS)
Juan Carlos Ferrero (ESP) v.  Gael Monfils (FRA)