Barcelona looking to bounce back from midweek defeat against Athletic Bilbao.
Kurt Zouma and Michy Batshuayi will start for Chelsea.
Ake has spent the first-half of the season on loan at Bournemouth.
Jon Toral is currently on loan at Granada.
Rojo was substituted after the 19th minute in the FA Cup tie against Reading.
Twelve-time winners Arsenal kick-off their campaign with victory at Deepdale.
The troubled former-footballer is seeking help for his alcohol addiction.
Championship high-flyers Reading eye a third round giant-klling at Old Trafford.
Nasri is currently on loan at Sevilla.
Griezmann is competing with Lionel Messi and Cristiano Ronaldo for Best Fifa Men's Player Award.
United were heavily linked with a move for Kostas Manolas and Victor Lindelof.
Henderson will miss Liverpool's next two fixtures against Plymouth and Southampton.
Mertesacker is yet to play this season after suffering a knee injury during pre-season.
Sanchez has 18 months left on his contract at Arsenal.
The last meeting between the two sides in the FA Cup was in 1999 when Arsenal won 4-2.
The 19-year-old midfielder will spend the season on loan at Go Ahead Eagles.
Matt Le Tissier says the Portugal international has behaved disrespectfully at St Mary's.
Everton and West Brom are reportedly after the former Southampton star.
Kurt Zouma is poised to return on Sunday, with John Terry also fit again.
Recent reports suggest Spurs have dropped interest in Crystal Palace's Wilfried Zaha.
Bastian Schweinsteiger may also feature as Jose Mourinho is ready to rotate his squad.
Manchester United are the holders of the FA Cup and will start their defence against Reading.
Fifa are set to agree on enlarging the event from 2026, but how have the finals grown?
Michy Batshuayi expected to come in for Diego Costa.
Portugal international is back in Zidane's 19-man squad after being rested against Sevilla.
The 23-year-old arrived on loan from Manchester United on Thursday.
Chinese transfer record has been broken five times in under a year.
Treble-winning defender heads back to Old Trafford in the third round of the FA Cup.
Catalans conceded two early goals, but Messi gave them some hope ahead of the second leg.
West Ham lost the league fixture against Manchester City 3-1.