South Africa's president Jacob Zuma has announced on national television he would resign with immediate effect.
He has faced down claims of corruption and a number of other controversies since he took the reins in 2009.
In a long speech on Wednesday, he said he was not happy with how his party had treated him, but added: "I have served the people of South Africa to the best of my ability."
"No life should be lost in my name and also the ANC should never be divided in my name.
"I have therefore come to the decision to resign as president of the republic with immediate effect," he said, according to the Associated Press.
"Even though I disagree with the decision of the leadership of my organisation, I have always been a disciplined member of the ANC. As I leave I will continue to serve the people of South Africa as well as the ANC, the organisation I have served... all of my life."
The ANC said in a statement that the resignation would mean there would be "certainty to the people of South Africa".
Cyril Ramaphosa, who is now the country's acting president, is expected to be elected swiftly in a parliament vote and sworn in.