North Korea has made yet another threat against the US saying it will not hesitate to launch a nuclear strike on the mainland if the Trump administration attempts to force a regime change in Pyongyang. The stinging warning comes after CIA Director Mike Pompeo spoke of regime change in North Korea.

An unnamed spokesperson for the North Korean foreign ministry has warned that if the "supreme dignity" of the North Korean leadership is harmed, the US has to face harsh consequences.

"Should the US dare to show even the slightest sign of [an] attempt to remove our supreme leadership, we will strike a merciless blow at the heart of the U.S. with our powerful nuclear hammer, honed and hardened over time," said the spokesperson, according to the Korean Central News Agency (KCNA).

Pompeo had earlier offered some aggressive comments on North Korea including the throwing a possibility replacing the reclusive regime led by the third-generation dictator, Kim Jong-un.

"It would be a great thing to denuclearize the peninsula, to get those weapons off of that, but the thing that is most dangerous about it is the character who holds the control over them today," the CIA chief said in a gathering.

He then went to say: "So from the administration's perspective, the most important thing we can do is separate those two. Right? Separate capacity and someone who might well have [an] intent and break those two apart."

North Korea is known to be extremely sensitive to comments related to its supreme leader, who is treated like a demigod figure inside the country. So, Pompeo's remarks unsurprisingly invoked the wrath of the North in its latest verbal assault.

"If the supreme dignity of the DPRK is threatened, (North Korea) must preemptively annihilate those countries and entities that are directly or indirectly involved in it by mobilising all kinds of strike means including the nuclear ones," read the KCNA report. "The likes of Pompeo will bitterly experience the catastrophic and miserable consequences caused by having dared to shake their little fists at the supreme leadership."