Damascus Syria Assad rebels
Heavily damaged buildings on the eastern outskirts of Damascus Sameer Al-Doumy/AFP

A car bomb rocked Syria's capital, killing at least eight people and wounding a dozen, in the biggest such attack in the Syrian capital since March.

The Interior Ministry said security forces tracked three cars loaded with explosives as they headed toward central Damascus.

Two of the cars were intercepted at checkpoints on the airport road and detonated, apparently in controlled explosions, while the third made it into the city centre, where the driver blew himself up near Tahreer Square.

However, the Syrian Minister of Local Administration, Hussein Makhlouf, said the response marked a "major success in foiling a plot" to cause mass casualties.

The attack came on the first full work day after the Eid al-Fitr holiday marking the end of the fasting month of Ramadan. State TV, which reported the toll, showed footage of two scorched vehicles on the airport road, as well as footage from Tahreer Square showing a damaged building and mangled cars at the small roundabout.

UK-based Syrian Observatory for Human Rights, an opposition monitoring group, put the death toll from the explosions at 12, including three attackers.

In March, two suicide bomb attacks in Damascus killed several dozen people, most of them at the Palace of Justice courthouse near the Old City. Islamic State claimed responsibility for that attack.

Rare attacks

Such attacks have been relatively rare in Damascus, the seat of power for President Bashar Assad, who made a series of public appearances last week in a show of increased confidence after more than six years of civil war.

Pro-government forces have engaged in heavy fighting in Damascus' suburbs during the war, but have largely kept the rebels out of the city centre.

In recent days, Syrian troops and allied forces have been fighting to drive the rebels out of Ain Terma and Jobar, adjacent areas on the city's eastern outskirts that have been under rebel control since 2011.

The attacks come days before Russian-sponsored talks are to resume in the Kazakh capital, Astana, where the two sides agreed to a cease-fire earlier this year that has been repeatedly violated.

The new round of talks is expected to delineate "de-escalation zones." Russian officials said the talks are also to discuss the formation of a Syrian national reconciliation committee.