Spurs produced a dominant performance against the Italian champions in Turin to secure a 2-2 draw in last month's first leg.
Head coach David Wagner has provided positive injury updates on seven Huddersfield players before Saturday's Premier League meeting with Tottenham at Wembley.
Lukaku struck very early and finished off wonderful counter-attack to punish the bright but toothless Terriers.
Mooy suffered a knee injury during Huddersfield's much-needed win over Bournemouth on Sunday (11 February) and could miss his side's next three matches.
Jurgen Klopp's side were knocked out of the FA Cup by West Bromwich Albion at Anfield over the weekend.
Kasey Palmer and Ike Ugbo have both returned to Stamford Bridge early after Chelsea opted to end their respective loan stints with Huddersfield Town and Barnsley.
Huddersfield have managed to keep their head above water during the first half of the season but will need to add an injection of creative quality to their frontline in January.
Tiemoue Bakayoko appears to have reignited his Chelsea career after producing the best performance of his tenure at the club, according to manager Antonio Conte
Premier League champions Chelsea get back to winning ways at newly-promoted Huddersfield while the Sean Dyche fairytale continues.
Rajiv van La Parra could return against Chelsea having served a three-match suspension after becoming embroiled in a bust-up with Leroy Sane against Manchester City.
Alexandre Lacazette will miss the visit of Manchester United on Saturday after the Arsenal striker suffered a groin injury during the win over Huddersfield.
The Gunners score three goals in four second-half minutes to confidently dispatch of Huddersfield, whose away-day blues continue at the Emirates Stadium.
Head coach David Wagner has no concerns over Huddersfield's fitness amid hectic fixture list, although will decide tomorrow whether to make changes for tough clash against Arsenal.
Arsene Wenger is undecided over his Arsenal team to face Huddersfield as insists he has the squad in order to rest in time to face Manchester United.
Sead Kolasinac and Aaron Ramsey both score as Arsenal recover from a first-half deficit to beat Paul Clement's Swansea at the Emirates Stadium.
Liverpool playmaker Philippe Coutinho is suffering with an adductor injury and is a doubt for Saturday's Premier League match against Huddersfield Town.
Jose Mourinho wants Manchester United players to show reaction against Tottenham after Huddersfield defeat
Jose Mourinho saw his side suffer a 2-1 defeat against Huddersfield Town in the last league tie. The Portuguese tactician wants his Manchester United players to bounce back against Tottenham.
Liverpool boss Jurgen Klopp says he would never let under-fire pair Simon Mignolet and Dejan Lovren down, although stopped short of confirming if they would be dropped.
David Wagner has confirmed that Elias Kachunga is available for Huddersfield's trip to Liverpool this weekend, while Collin Quaner could also feature.
Liverpool will be without the services of forward Sadio Mane, midfielder Adam Lallana, full-back Nathaniel Clyne and backup goalkeeper Adam Bogdan.
Huddersfield will be without Philip Billing for up to 12 weeks after the Danish Under-21 international underwent surgery on an ankle injury suffered at Swansea.
Manchester United striker Anthony Martial avoids retrospective ban for kick on Huddersfield's Tommy Smith
Anthony Martial has avoided retrospective punishment for an alleged kick-out at Huddersfield's Tommy Smith during the Premier league defeat.
Everton place David Unsworth in temporary charge as Toffees begin search for Ronald Koeman's successor
Unsworth will lead the Toffees against Chelsea on Wednesday (25 October) and will also be in control for the games against Leicester City, Watford and Lyon.
Shock defeat raises importance of United's Premier League clash with Tottenham at Old Trafford, former England defender says.
The Huddersfield Town forward says United are quite slow in building up the game.
Mourinho was unhappy with Ander Herrera's claim that Huddersfield played with "more passion" than the Red Devils.