Arsenal's Premier League title hopes and England's World Cup preparations have suffered a major blow after the club confirmed Jack Wilshere will be out of action for a minimum of six weeks after suffering a hairline fracture to his left foot.

The 22-year-old suffered the injury during the Three Lions' friendly victory over Denmark at Wembley on Wednesday following a challenge from Liverpool's Daniel Agger after 12 minutes of play, but stayed on the pitch for an hour.

Arsenal's statement claims Wilshere will spend at least six weeks on the side-lines before he begins his rehabilitation programme, throwing his preparation plans for the World Cup in Brazil into uncertainty.

Initial scans carried out by the FA discovered a "hairline fracture to the navicular bone" which rules the midfielder out for at least nine games, including the north London derby against Tottenham Hotspur in 10 days time.

Arsenal take on Everton in their FA Cup quarter final tie on Saturday afternoon before they travel to the Allianz Arena for their Champions League second leg clash against Bayern Munich on Tuesday.

Meanwhile, Aaron Ramsey is still unfit after being out for over two months with a thigh injury but he may return for the game against the Spurs.

Kim Kallstrom is also nearing a return having been side-lined since his January move to the Emirates Stadium and may be thrown straight into the first team given Wilshere's prolonged absence.

Wilshere has been a pivotal player for Wenger this season, having started 19 Premier League games, scoring three goals and grabbing 5 assists.

His influence within the Gunners' side has increased recently due to Aaron Ramsey's injury but Arsene Wenger now faces the challenge of supplementing the midfielder's absence as his side battle Chelsea, Manchester City and Liverpool for the Premier League title.