Liverpool striker Daniel Sturridge has pulled out of the England squad after sustaining an injury during the Reds' loss to Manchester United on Sunday.
The Three Lions forward, who spent five months on the sidelines after picking up an injury on international duty in September, was looking to play a part in England's Euro 2016 qualifier against Lithuania on Friday and their friendly against Italy four days later.
The former Chelsea forward is Roy Hodgson's first-choice striker and his absence could hand Tottenham striker Harry Kane the opportunity to make his debut for the senior Three Lions team.
The Liverpool forward travelled with the England squad to St George's Park but failed to train with the team due to the injury and the FA have confirmed that the striker has returned to the club and will miss the entirety of the international break.
"Liverpool striker Daniel Sturridge has left the England squad and returned home to his club on Monday evening. This follows a scan on an injury that he sustained during Liverpool's game against Manchester United on Sunday," a statement read on the FA website.
"The England medical team took the decision on Monday evening, having assessed Daniel following the squad's arrival at St George's Park on Monday afternoon."
Sturridge is not the only player to have withdrawn from the squad as his Liverpool teammate Adam Lallana had already pulled out of the games against Lithuania and Italy after sustaining a groin injury during the game against United at Anfield on Sunday.
With a big game against Arsenal coming up following the international break, Brendan Rodgers could be without key players for a game that could be a factor in deciding whether they finish in the top four or not.
Apart from the injured duo, the Merseyside club will be without Steven Gerrard, who will be suspended following his red card against the Red Devils. He could also be without Martin Sktel, as the defender was charged by the FA for a stamp on David de Gea late in the game.